{"id":1004,"date":"2026-06-24T21:03:28","date_gmt":"2026-06-24T21:03:28","guid":{"rendered":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/?post_type=product&p=1004"},"modified":"2026-09-02T13:17:00","modified_gmt":"2026-09-02T13:17:00","slug":"kpv","status":"publish","type":"product","link":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/product\/kpv\/","title":{"rendered":"KPV"},"content":{"rendered":"

KPV \u2013 5mg \/ 10mg<\/strong>
\nThe C-Terminal Tripeptide of alpha-MSH for Inflammation Research
\nA Lys-Pro-Val Melanocortin Tripeptide for Anti-Inflammatory Pathway Studies<\/p>\n

Category: Peptide Research Compounds \/ Inflammation \/ Melanocortin Biology<\/strong><\/p>\n

For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive. Intended exclusively for in-vitro and laboratory research by qualified investigators.<\/p>\n

DISCLAIMER<\/strong>
\nATTENTION:<\/strong> PRIMALRESEARCHLABS.COM<\/strong> products are intended for laboratory research and in-vitro studies only. All information presented is for educational and research purposes related to scientific investigation. These products are strictly not for human or veterinary use, consumption, or diagnostic applications. They are not pharmaceuticals, food additives, or dietary supplements. By purchasing from PRIMALRESEARCHLABS.COM<\/strong>, you acknowledge that you are a qualified researcher operating in a controlled laboratory environment. Adhere to all applicable local, state, and federal laws and regulations regarding handling and use of research chemicals. Use appropriate personal protective equipment (PPE) and follow laboratory safety protocols.<\/p>\n

BIOLOGY<\/strong>
\nKPV is a tripeptide (Lys-Pro-Val) corresponding to the C-terminal sequence (residues 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite its small size, KPV retains notable anti-inflammatory activity and is studied for its ability to modulate inflammatory signaling without inducing the pigmentary effects associated with full-length alpha-MSH.<\/p>\n

KPV has been investigated in preclinical research models examining intestinal inflammation, NF-kappaB and MAP kinase signaling, and pro-inflammatory cytokine expression. Research indicates KPV can be transported into cells via the PepT1 di\/tripeptide transporter, where it modulates intracellular inflammatory pathways. These properties make it a valuable tool for in-vitro and in-vivo inflammation research.<\/p>\n

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.<\/p>\n

KEY RESEARCH APPLICATIONS OF KPV<\/strong><\/p>\n

1. Anti-Inflammatory Signaling<\/strong>
\nKPV demonstrates significant activity in inflammation studies through:
\n\u2022 NF-kappaB Modulation: Inhibits activation of NF-kappaB inflammatory signaling.
\n\u2022 MAP Kinase Pathways: Studied for downregulation of MAPK inflammatory cascades.
\n\u2022 Cytokine Reduction: Reduces secretion of pro-inflammatory cytokines in cell models.
\nSupporting Studies:
\nDalmasso, G. et al. \u2014 Gastroenterology. \u201cPepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.\u201d PubMed \u2013 PMID: 18061177<\/p>\n

2. Intestinal & Mucosal Inflammation<\/strong>
\nInvestigated in gastrointestinal inflammation models through:
\n\u2022 Colitis Models: Examined in DSS- and TNBS-induced experimental colitis.
\n\u2022 Epithelial Cell Response: Studied in intestinal epithelial cell cultures.
\n\u2022 PepT1 Transport: Uptake mediated by the PepT1 di\/tripeptide transporter.
\nSupporting Studies:
\nKannengiesser, K. et al. \u2014 Inflammatory Bowel Diseases. \u201cMelanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.\u201d PubMed \u2013 PMID: 18092346<\/p>\n

3. Melanocortin Pathway Research<\/strong>
\nExplored in broader inflammation research through:
\n\u2022 Leukocyte Migration: Studied for antimigratory effects in peritonitis models.
\n\u2022 Receptor-Independent Action: Activity studied independent of melanocortin receptors.
\n\u2022 Comparative Peptide Studies: Reference fragment within alpha-MSH research.
\nSupporting Studies:
\nGetting, S.J. et al. \u2014 British Journal of Pharmacology. \u201cDissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.\u201d PubMed \u2013 PMID: 12750433<\/p>\n

RECOMMENDED RESEARCH CONCENTRATIONS<\/strong>
\nFor laboratory research reference only. Not for human or veterinary use.
\n\u2022 In-vitro inflammation assays \u2014 1-100 nM \u2014 Assay buffer
\n\u2022 Epithelial cell culture \u2014 1-100 \u00b5M \u2014 Cell culture media
\n\u2022 Animal models (rodents) \u2014 Per protocol \u2014 Oral \/ SC<\/p>\n

WHY CHOOSE PRIMAL RESEARCH FOR YOUR KPV STUDIES?<\/strong>
\n\u2022 \u226598% HPLC-verified purity \u2014 critical for inflammation signaling studies
\n\u2022 Independent third-party batch testing with COA available on request
\n\u2022 Lyophilized powder for maximum stability and long-term storage
\n\u2022 Available in 5mg and 10mg quantities \u2014 supports scalable inflammation protocols<\/p>\n

STORAGE & HANDLING<\/strong>
\n\u2022 Store at -20\u00b0C, desiccated and protected from light
\n\u2022 Soluble in sterile water or bacteriostatic water
\n\u2022 Prepare fresh solutions prior to each experiment
\n\u2022 Avoid repeated freeze-thaw cycles<\/p>\n

TECHNICAL SPECIFICATIONS<\/strong>
\nCompound: KPV (Lys-Pro-Val)
\nMolecular Weight: ~342 g\/mol
\nPurity: \u226598% (HPLC Verified)
\nForm: Lyophilized powder \u2014 5mg and 10mg
\nStorage: -20\u00b0C, desiccated, light-protected
\nSolubility: Soluble in sterile or bacteriostatic water
\nCOA: Available per batch on request<\/p>\n

ADVANCE YOUR RESEARCH<\/strong>
\nOrder your KPV today to support advanced research in melanocortin biology, anti-inflammatory signaling, and intestinal inflammation modeling.<\/p>\n

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"excerpt":{"rendered":"

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"featured_media":1005,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[80],"product_tag":[],"class_list":["post-1004","product","type-product","status-publish","has-post-thumbnail","product_cat-tissue-cellular-research","pa_packaging-10mg","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product\/1004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media\/1005"}],"wp:attachment":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media?parent=1004"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_brand?post=1004"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_cat?post=1004"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_tag?post=1004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}