{"id":477,"date":"2026-03-31T23:08:49","date_gmt":"2026-03-31T23:08:49","guid":{"rendered":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/?post_type=product&#038;p=477"},"modified":"2026-09-02T20:28:27","modified_gmt":"2026-09-02T20:28:27","slug":"sermorelin","status":"publish","type":"product","link":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/product\/sermorelin\/","title":{"rendered":"Sermorelin"},"content":{"rendered":"<h2 data-section-id=\"1u6azx7\" data-start=\"218\" data-end=\"309\">Growth Hormone Releasing Hormone (GHRH) Analog | Endocrine &amp; GH Axis Research Compound<\/h2>\n<p data-start=\"311\" data-end=\"414\"><strong data-start=\"311\" data-end=\"412\">For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.<\/strong><\/p>\n<p data-start=\"416\" data-end=\"503\">Intended exclusively for in-vitro and laboratory research by qualified investigators.<\/p>\n<p data-start=\"505\" data-end=\"597\"><strong data-start=\"505\" data-end=\"525\">Sermorelin \u2013 5mg<\/strong><br data-start=\"525\" data-end=\"528\" \/>A GHRH (1\u201329) Analog for Growth Hormone Axis and Endocrine Research<\/p>\n<p data-start=\"599\" data-end=\"684\"><strong data-start=\"599\" data-end=\"612\">Category:<\/strong> Peptide Research Compounds \/ Endocrinology Research \/ GH Axis Biology<\/p>\n<hr data-start=\"686\" data-end=\"689\" \/>\n<h3 data-section-id=\"1ajl8cl\" data-start=\"691\" data-end=\"707\">Disclaimer<\/h3>\n<p data-start=\"709\" data-end=\"914\"><strong data-start=\"709\" data-end=\"723\">ATTENTION:<\/strong> PrimalResearchLabs.com products are intended for laboratory research and in-vitro studies only. All information is for educational and research purposes related to scientific investigation.<\/p>\n<p data-start=\"916\" data-end=\"1097\">These products are strictly <strong data-start=\"944\" data-end=\"951\">not<\/strong> for human or veterinary use, consumption, or diagnostic applications. They are <strong data-start=\"1031\" data-end=\"1038\">not<\/strong> pharmaceuticals, food additives, or dietary supplements.<\/p>\n<p data-start=\"1099\" data-end=\"1407\">By purchasing from PrimalResearchLabs.com, you acknowledge that you are a qualified researcher operating in a controlled laboratory environment. Follow all applicable local, state, and federal laws regarding handling and use of research chemicals. Use appropriate PPE and follow laboratory safety protocols.<\/p>\n<hr data-start=\"1409\" data-end=\"1412\" \/>\n<h3 data-section-id=\"1e3qyhr\" data-start=\"1414\" data-end=\"1427\">Biology<\/h3>\n<p data-start=\"1429\" data-end=\"1669\">Sermorelin is a synthetic peptide representing the first 29 amino acids of endogenous <strong data-start=\"1515\" data-end=\"1563\">growth hormone-releasing hormone (GHRH 1\u201329)<\/strong>, the biologically active fragment responsible for stimulating GH secretion from the anterior pituitary.<\/p>\n<p data-start=\"1671\" data-end=\"2052\">Sermorelin stimulates <strong data-start=\"1693\" data-end=\"1731\">physiologic pulsatile GH secretion<\/strong>, preserving natural regulatory feedback mechanisms within the hypothalamic-pituitary axis. Unlike exogenous GH administration, it promotes <strong data-start=\"1871\" data-end=\"1904\">endogenous hormone production<\/strong>, making it a valuable tool for in-vitro and in-vivo studies across GH deficiency models, metabolic research, and endocrine pathway investigation.<\/p>\n<p data-start=\"2054\" data-end=\"2181\">This product is intended solely for in-vitro and preclinical research use and is <strong data-start=\"2135\" data-end=\"2142\">not<\/strong> for human or veterinary consumption.<\/p>\n<hr data-start=\"2183\" data-end=\"2186\" \/>\n<h3 data-section-id=\"1vdjjma\" data-start=\"2188\" data-end=\"2233\">Key Research Applications of Sermorelin<\/h3>\n<h4 data-start=\"2235\" data-end=\"2294\">1. Growth Hormone Secretion &amp; GHRH Receptor Research<\/h4>\n<ul data-start=\"2296\" data-end=\"2604\">\n<li data-section-id=\"ztdmci\" data-start=\"2296\" data-end=\"2399\"><strong data-start=\"2298\" data-end=\"2327\">GHRH Receptor Activation:<\/strong> Stimulates GH release via direct binding to pituitary GHRH receptors.<\/li>\n<li data-section-id=\"pie1jk\" data-start=\"2400\" data-end=\"2498\"><strong data-start=\"2402\" data-end=\"2429\">Pulsatile GH Secretion:<\/strong> Preserves physiologic GH release patterns and feedback regulation.<\/li>\n<li data-section-id=\"1r6l4af\" data-start=\"2499\" data-end=\"2604\"><strong data-start=\"2501\" data-end=\"2530\">Endocrine Axis Integrity:<\/strong> Maintains hypothalamic-pituitary control mechanisms in research models.<\/li>\n<\/ul>\n<p data-start=\"2606\" data-end=\"2816\"><strong data-start=\"2606\" data-end=\"2629\">Supporting Studies:<\/strong><br data-start=\"2629\" data-end=\"2632\" \/>Thorner, M.O. et al. \u2014 <em data-start=\"2655\" data-end=\"2690\">Journal of Clinical Investigation<\/em><br data-start=\"2690\" data-end=\"2693\" \/><em data-start=\"2693\" data-end=\"2789\">&#8220;GHRH (1\u201329) stimulates growth hormone release through specific receptor-mediated mechanisms.&#8221;<\/em><br data-start=\"2789\" data-end=\"2792\" \/>PubMed \u2013 PMID: 3086132<\/p>\n<hr data-start=\"2818\" data-end=\"2821\" \/>\n<h4 data-start=\"2823\" data-end=\"2878\">2. GH\/IGF-1 Axis &amp; Metabolic Regulation Research<\/h4>\n<ul data-start=\"2880\" data-end=\"3137\">\n<li data-section-id=\"ktrxho\" data-start=\"2880\" data-end=\"2960\"><strong data-start=\"2882\" data-end=\"2903\">IGF-1 Production:<\/strong> Increases circulating IGF-1 via GH-mediated signaling.<\/li>\n<li data-section-id=\"awin94\" data-start=\"2961\" data-end=\"3057\"><strong data-start=\"2963\" data-end=\"2994\">Metabolic Function Support:<\/strong> Influences lipid metabolism and glucose regulation pathways.<\/li>\n<li data-section-id=\"23ybaw\" data-start=\"3058\" data-end=\"3137\"><strong data-start=\"3060\" data-end=\"3092\">Endocrine Response Modeling:<\/strong> Useful for GH-dependent metabolic studies.<\/li>\n<\/ul>\n<p data-start=\"3139\" data-end=\"3364\"><strong data-start=\"3139\" data-end=\"3162\">Supporting Studies:<\/strong><br data-start=\"3162\" data-end=\"3165\" \/>Gelato, M.C. et al. \u2014 <em data-start=\"3187\" data-end=\"3235\">Journal of Clinical Endocrinology &amp; Metabolism<\/em><br data-start=\"3235\" data-end=\"3238\" \/><em data-start=\"3238\" data-end=\"3336\">&#8220;Sermorelin stimulates GH secretion and increases IGF-1 levels in controlled endocrine studies.&#8221;<\/em><br data-start=\"3336\" data-end=\"3339\" \/>PubMed \u2013 PMID: 11701438<\/p>\n<hr data-start=\"3366\" data-end=\"3369\" \/>\n<h4 data-start=\"3371\" data-end=\"3416\">3. Aging &amp; Endocrine Function Research<\/h4>\n<ul data-start=\"3418\" data-end=\"3722\">\n<li data-section-id=\"192kvc4\" data-start=\"3418\" data-end=\"3519\"><strong data-start=\"3420\" data-end=\"3447\">Age-Related GH Decline:<\/strong> Investigated in models of reduced GH secretion associated with aging.<\/li>\n<li data-section-id=\"rxm4x7\" data-start=\"3520\" data-end=\"3613\"><strong data-start=\"3522\" data-end=\"3551\">Hormonal Balance Studies:<\/strong> Supports evaluation of endocrine system function over time.<\/li>\n<li data-section-id=\"1qiz233\" data-start=\"3614\" data-end=\"3722\"><strong data-start=\"3616\" data-end=\"3659\">Physiologic Hormone Restoration Models:<\/strong> Used in studies examining restoration of natural GH rhythms.<\/li>\n<\/ul>\n<p data-start=\"3724\" data-end=\"3923\"><strong data-start=\"3724\" data-end=\"3747\">Supporting Studies:<\/strong><br data-start=\"3747\" data-end=\"3750\" \/>Corpas, E. et al. \u2014 <em data-start=\"3770\" data-end=\"3818\">Journal of Clinical Endocrinology &amp; Metabolism<\/em><br data-start=\"3818\" data-end=\"3821\" \/><em data-start=\"3821\" data-end=\"3896\">&#8220;Growth hormone-releasing hormone restores GH secretion in aging models.&#8221;<\/em><br data-start=\"3896\" data-end=\"3899\" \/>PubMed \u2013 PMID: 8188727<\/p>\n<hr data-start=\"3925\" data-end=\"3928\" \/>\n<h3 data-section-id=\"i4vv9k\" data-start=\"3930\" data-end=\"3971\">Recommended Research Concentrations<\/h3>\n<p data-start=\"3973\" data-end=\"4049\"><em data-start=\"3973\" data-end=\"4047\">For laboratory research reference only. Not for human or veterinary use.<\/em><\/p>\n<div class=\"TyagGW_tableContainer\">\n<div class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\" tabindex=\"-1\">\n<table class=\"w-fit min-w-(--thread-content-width)\" data-start=\"4051\" data-end=\"4471\">\n<thead data-start=\"4051\" data-end=\"4136\">\n<tr data-start=\"4051\" data-end=\"4136\">\n<th class=\"\" data-start=\"4051\" data-end=\"4083\" data-col-size=\"sm\">Research Model<\/th>\n<th class=\"\" data-start=\"4083\" data-end=\"4109\" data-col-size=\"sm\">Suggested Concentration<\/th>\n<th class=\"\" data-start=\"4109\" data-end=\"4136\" data-col-size=\"sm\">Administration<\/th>\n<\/tr>\n<\/thead>\n<tbody data-start=\"4221\" data-end=\"4471\">\n<tr data-start=\"4221\" data-end=\"4304\">\n<td data-start=\"4221\" data-end=\"4254\" data-col-size=\"sm\">In-vitro receptor assays<\/td>\n<td data-start=\"4254\" data-end=\"4278\" data-col-size=\"sm\">1\u2013100 nM<\/td>\n<td data-col-size=\"sm\" data-start=\"4278\" data-end=\"4304\">Assay buffer<\/td>\n<\/tr>\n<tr data-start=\"4305\" data-end=\"4388\">\n<td data-start=\"4305\" data-end=\"4338\" data-col-size=\"sm\">GH secretion studies<\/td>\n<td data-col-size=\"sm\" data-start=\"4338\" data-end=\"4362\">1\u2013100 nM<\/td>\n<td data-col-size=\"sm\" data-start=\"4362\" data-end=\"4388\">Cell culture media<\/td>\n<\/tr>\n<tr data-start=\"4389\" data-end=\"4471\">\n<td data-start=\"4389\" data-end=\"4421\" data-col-size=\"sm\">Animal models (rodents, SC)<\/td>\n<td data-col-size=\"sm\" data-start=\"4421\" data-end=\"4445\">0.1\u20131 mg\/kg<\/td>\n<td data-col-size=\"sm\" data-start=\"4445\" data-end=\"4471\">Injection<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<hr data-start=\"4473\" data-end=\"4476\" \/>\n<h3 data-section-id=\"1gvfn75\" data-start=\"4478\" data-end=\"4526\">Why Choose Primal Research for Sermorelin?<\/h3>\n<ul data-start=\"4528\" data-end=\"4828\">\n<li data-section-id=\"1sa2xcd\" data-start=\"4528\" data-end=\"4619\">\u226598% HPLC-verified purity \u2014 critical for GHRH receptor binding and GH secretion studies<\/li>\n<li data-section-id=\"1xb8uq\" data-start=\"4620\" data-end=\"4680\">Independent third-party batch testing with COA available<\/li>\n<li data-section-id=\"1a996h7\" data-start=\"4681\" data-end=\"4747\">Lyophilized powder for maximum stability and long-term storage<\/li>\n<li data-section-id=\"13m42tb\" data-start=\"4748\" data-end=\"4828\">Available in 5mg quantity \u2014 supports controlled endocrine research protocols<\/li>\n<\/ul>\n<hr data-start=\"4830\" data-end=\"4833\" \/>\n<h3 data-section-id=\"1ohezx2\" data-start=\"4835\" data-end=\"4859\">Storage &amp; Handling<\/h3>\n<ul data-start=\"4861\" data-end=\"5061\">\n<li data-section-id=\"xpt31v\" data-start=\"4861\" data-end=\"4917\">Store at <strong data-start=\"4872\" data-end=\"4881\">-20\u00b0C<\/strong>, desiccated, protected from light<\/li>\n<li data-section-id=\"19iv2pd\" data-start=\"4918\" data-end=\"4970\">Soluble in sterile water or bacteriostatic water<\/li>\n<li data-section-id=\"la3m0a\" data-start=\"4971\" data-end=\"5023\">Prepare fresh solutions prior to each experiment<\/li>\n<li data-section-id=\"1jakekk\" data-start=\"5024\" data-end=\"5061\">Avoid repeated freeze-thaw cycles<\/li>\n<\/ul>\n<hr data-start=\"5063\" data-end=\"5066\" \/>\n<h3 data-section-id=\"12xlpaz\" data-start=\"5068\" data-end=\"5098\">Technical Specifications<\/h3>\n<ul data-start=\"5100\" data-end=\"5432\">\n<li data-section-id=\"hn3b9w\" data-start=\"5100\" data-end=\"5140\"><strong data-start=\"5102\" data-end=\"5115\">Compound:<\/strong> Sermorelin (GHRH 1\u201329)<\/li>\n<li data-section-id=\"a3u5fu\" data-start=\"5141\" data-end=\"5178\"><strong data-start=\"5143\" data-end=\"5164\">Molecular Weight:<\/strong> ~3357 g\/mol<\/li>\n<li data-section-id=\"16nf1ps\" data-start=\"5179\" data-end=\"5215\"><strong data-start=\"5181\" data-end=\"5192\">Purity:<\/strong> \u226598% (HPLC Verified)<\/li>\n<li data-section-id=\"r6f2pr\" data-start=\"5216\" data-end=\"5267\"><strong data-start=\"5218\" data-end=\"5227\">Form:<\/strong> Lyophilized powder \u2014 available in 5mg<\/li>\n<li data-section-id=\"keq83l\" data-start=\"5268\" data-end=\"5319\"><strong data-start=\"5270\" data-end=\"5282\">Storage:<\/strong> -20\u00b0C, desiccated, light-protected<\/li>\n<li data-section-id=\"1aj63u5\" data-start=\"5320\" data-end=\"5388\"><strong data-start=\"5322\" data-end=\"5337\">Solubility:<\/strong> Soluble in sterile water or bacteriostatic water<\/li>\n<li data-section-id=\"94xhu5\" data-start=\"5389\" data-end=\"5432\"><strong data-start=\"5391\" data-end=\"5399\">COA:<\/strong> Available per batch on request<\/li>\n<\/ul>\n<hr data-start=\"5434\" data-end=\"5437\" \/>\n<h3 data-section-id=\"1gvrynb\" data-start=\"5439\" data-end=\"5476\">Advance Your Endocrine Research<\/h3>\n<p data-start=\"5478\" data-end=\"5622\">Order your <strong data-start=\"5489\" data-end=\"5507\">Sermorelin 5mg<\/strong> today to support advanced research in <strong data-start=\"5546\" data-end=\"5619\">growth hormone signaling, endocrine biology, and metabolic regulation<\/strong>.<\/p>\n<p data-start=\"5624\" data-end=\"5933\">Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"featured_media":244,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[79],"product_tag":[],"class_list":["post-477","product","type-product","status-publish","has-post-thumbnail","product_cat-research-blends","pa_packaging-5mg","first","instock","shipping-taxable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product\/477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media\/244"}],"wp:attachment":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media?parent=477"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_brand?post=477"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_cat?post=477"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_tag?post=477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}