{"id":522,"date":"2026-03-31T23:38:48","date_gmt":"2026-03-31T23:38:48","guid":{"rendered":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/?post_type=product&p=522"},"modified":"2026-09-02T20:24:06","modified_gmt":"2026-09-02T20:24:06","slug":"melanotan-ii","status":"publish","type":"product","link":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/product\/melanotan-ii\/","title":{"rendered":"Melanotan II"},"content":{"rendered":"

Melanotan II | Synthetic Melanocortin Analog Research Compound<\/strong><\/span><\/h2>\n

For Research Use Only.<\/strong> Not for human or veterinary use. Not a drug, supplement, or food additive.
Intended exclusively for in-vitro and laboratory research by qualified investigators.<\/p>\n

Available Quantity:<\/strong> 10mg
Category:<\/strong> Peptide Research Compounds \/ Endocrinology Research \/ Melanocortin System Biology<\/p>\n

\n

Disclaimer<\/strong><\/span><\/h3>\n

ATTENTION:<\/strong> Products from PrimalResearchLabs.com are intended strictly for laboratory research and in-vitro studies.<\/p>\n

    \n
  • All information provided is for educational and scientific research purposes only.<\/li>\n
  • These products are not pharmaceuticals, dietary supplements, or food additives.<\/li>\n
  • Not for human or veterinary consumption, or diagnostic applications.<\/li>\n
  • Purchasers must be qualified researchers operating in controlled laboratory settings and comply with all applicable local, state, and federal regulations.<\/li>\n
  • Handle all materials using appropriate personal protective equipment (PPE) and follow laboratory safety protocols.<\/li>\n<\/ul>\n
    \n

    Biology<\/strong><\/span><\/h3>\n

    Melanotan II is a synthetic cyclic heptapeptide analog of \u03b1-melanocyte-stimulating hormone (\u03b1-MSH), designed to enhance receptor affinity and resist enzymatic degradation.<\/p>\n

    It acts primarily as an agonist at melanocortin receptors (MC1R, MC3R, MC4R), influencing pigmentation, appetite regulation, and neuroendocrine signaling pathways.<\/p>\n

    Melanotan II has been extensively studied in preclinical and clinical models for:<\/p>\n

      \n
    • Stimulating melanogenesis<\/li>\n
    • Modulating energy balance<\/li>\n
    • Influencing CNS pathways related to behavior and endocrine regulation<\/li>\n<\/ul>\n

      Its receptor specificity and stability make it a valuable tool for in-vitro and in-vivo experimental design across pigmentation biology, metabolic research, and neuroendocrine studies.<\/p>\n

      Intended exclusively for laboratory research and preclinical applications.<\/p>\n

      \n

      Key Research Applications<\/strong><\/span><\/h3>\n

      1. Melanogenesis & Pigmentation Research<\/strong><\/p>\n

        \n
      • MC1R Activation:<\/strong> Stimulates melanocyte activity, increasing eumelanin production<\/li>\n
      • Tyrosinase Upregulation:<\/strong> Enhances enzymatic pathways for melanin synthesis<\/li>\n
      • UV-Independent Pigmentation:<\/strong> Induces pigmentation without ultraviolet exposure<\/li>\n<\/ul>\n

        Supporting Study:<\/em> Abdel-Malek, Z. et al. \u2014 Pigment Cell Research<\/em> (PMID: 16965269)<\/p>\n

        2. Appetite Regulation & Energy Homeostasis<\/strong><\/p>\n

          \n
        • MC4R Activation:<\/strong> Suppresses appetite through hypothalamic melanocortin pathways<\/li>\n
        • Energy Balance:<\/strong> Modulates caloric intake and energy expenditure<\/li>\n
        • Obesity Models:<\/strong> Demonstrates reduced food intake in experimental animals<\/li>\n<\/ul>\n

          Supporting Study:<\/em> Fan, W. et al. \u2014 Nature<\/em> (PMID: 9525855)<\/p>\n

          3. Neuroendocrine & Behavioral Research<\/strong><\/p>\n

            \n
          • Hypothalamic Signaling:<\/strong> Modulates neuroendocrine pathways controlling hormonal responses<\/li>\n
          • Dopaminergic Interaction:<\/strong> Influences CNS reward pathways<\/li>\n
          • Endocrine System Modulation:<\/strong> Integrates peptide signaling with hormonal networks<\/li>\n<\/ul>\n

            Supporting Study:<\/em> Wessells, H. et al. \u2014 Journal of Urology<\/em> (PMID: 18639247)<\/p>\n

            \n

            Recommended Research Concentrations<\/strong><\/span><\/h3>\n
            \n
            \n\n\n\n\n\n\n\n
            Research Model<\/th>\nSuggested Concentration<\/th>\nAdministration<\/th>\n<\/tr>\n<\/thead>\n
            In-vitro receptor assays<\/td>\n1\u2013100 nM<\/td>\nAssay buffer<\/td>\n<\/tr>\n
            Melanocyte studies<\/td>\n1\u201310 \u00b5M<\/td>\nCell culture media<\/td>\n<\/tr>\n
            Animal models (rodents, SC)<\/td>\n0.1\u20131 mg\/kg<\/td>\nInjection<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n
            \n

            Why Choose Primal Research for Melanotan II?<\/strong><\/span><\/h3>\n
              \n
            • \u226598% HPLC-verified purity \u2014 essential for reproducible melanocortin receptor studies<\/li>\n
            • Independent third-party batch testing; COA available on request<\/li>\n
            • Lyophilized powder for stability and long-term storage<\/li>\n
            • Available in 10mg \u2014 supports controlled experimental and longitudinal research<\/li>\n<\/ul>\n
              \n

              Storage & Handling<\/strong><\/span><\/h3>\n
                \n
              • Store at -20\u00b0C, desiccated and protected from light<\/li>\n
              • Soluble in sterile water or bacteriostatic water<\/li>\n
              • Prepare fresh solutions prior to each experiment<\/li>\n
              • Avoid repeated freeze-thaw cycles<\/li>\n<\/ul>\n
                \n

                Technical Specifications<\/strong><\/span><\/h3>\n
                  \n
                • Compound:<\/strong> Melanotan II<\/li>\n
                • Molecular Weight:<\/strong> ~1024.2 g\/mol<\/li>\n
                • Molecular Formula:<\/strong> C50H69N15O9<\/li>\n
                • Purity:<\/strong> \u226598% (HPLC Verified)<\/li>\n
                • Form:<\/strong> Lyophilized powder \u2014 10mg<\/li>\n
                • Solubility:<\/strong> Soluble in sterile or bacteriostatic water<\/li>\n
                • COA:<\/strong> Available per batch on request<\/li>\n<\/ul>\n
                  \n

                  Advance Your Pigmentation & Neuroendocrine Research<\/strong><\/span><\/h3>\n

                  Order Melanotan II 10mg today to support advanced research in melanocortin signaling, pigmentation biology, and metabolic regulation.<\/p>\n

                  \n

                  Final Disclaimer<\/strong><\/span><\/h3>\n

                  Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"excerpt":{"rendered":"

                  Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"featured_media":473,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[82],"product_tag":[],"class_list":["post-522","product","type-product","status-publish","has-post-thumbnail","product_cat-melanocortin-research","pa_packaging-10mg","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product\/522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media\/473"}],"wp:attachment":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media?parent=522"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_brand?post=522"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_cat?post=522"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_tag?post=522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}