{"id":534,"date":"2026-03-31T23:51:15","date_gmt":"2026-03-31T23:51:15","guid":{"rendered":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/?post_type=product&p=534"},"modified":"2026-09-02T20:25:08","modified_gmt":"2026-09-02T20:25:08","slug":"mots-c","status":"publish","type":"product","link":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/product\/mots-c\/","title":{"rendered":"MOTS-c"},"content":{"rendered":"

Mitochondrial-Derived Peptide | Metabolic & Cellular Energy Research Compound<\/strong><\/span><\/h2>\n
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\u25a0 For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.<\/p>\n

Intended exclusively for in-vitro and laboratory research by qualified investigators.<\/p>\n

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MOTS-c \u2013 10mg \/ 20mg \/ 40mg \u2013 A Mitochondrial-Derived Peptide for Metabolic Regulation and Cellular Energy Research<\/strong><\/p>\n

Category:<\/strong> Peptide Research Compounds \/ Metabolic Research \/ Mitochondrial Biology<\/p>\n

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Disclaimer:<\/strong><\/span><\/h2>\n

ATTENTION: PRIMALRESEARCHLABS.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY.<\/p>\n

All information presented on this site is for educational and research purposes related to scientific investigation.<\/p>\n

These products are strictly not for human or veterinary use, consumption, or diagnostic applications.<\/p>\n

They are not pharmaceuticals, food additives, or dietary supplements.<\/p>\n

By purchasing from PrimalResearchLabs.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment.<\/p>\n

You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals.<\/p>\n

Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.<\/p>\n

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Biology<\/strong><\/span><\/h2>\n

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide encoded within the mitochondrial genome, representing a novel class of signaling molecules that link mitochondrial function to nuclear gene expression.<\/p>\n

It has been extensively studied in preclinical models for its role in metabolic homeostasis, insulin sensitivity, and cellular stress response pathways.<\/p>\n

MOTS-c is of particular interest in metabolic research due to its ability to translocate to the nucleus under metabolic stress conditions and regulate genes involved in energy metabolism, glucose utilization, and oxidative stress resistance.<\/p>\n

Its unique role as a mitochondria-to-nucleus signaling peptide makes it a valuable tool for in-vitro and in-vivo experimental design across metabolic disease models, mitochondrial biology, and aging research.<\/p>\n

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.<\/p>\n

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Key Research Applications of MOTS-c<\/strong><\/span><\/h2>\n

Metabolic Regulation & Insulin Sensitivity Research<\/strong><\/span><\/h3>\n

MOTS-c has demonstrated significant activity in metabolic studies through:<\/p>\n

AMPK Activation \u2014 Enhances glucose uptake and fatty acid oxidation via activation of AMP-activated protein kinase pathways.<\/p>\n

Insulin Sensitivity Improvement \u2014 Improves insulin signaling and glucose homeostasis in experimental models.<\/p>\n

Obesity Model Research \u2014 Reduces weight gain and improves metabolic markers in diet-induced obesity models.<\/p>\n

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Supporting Studies:<\/strong><\/span><\/h3>\n

Lee, C. et al. \u2014 Cell Metabolism.<\/p>\n

\u201cThe mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis and insulin sensitivity.\u201d<\/p>\n

\u25a0 PubMed \u2013 PMID: 25651178<\/p>\n

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Mitochondrial Function & Cellular Stress Response Research<\/strong><\/span><\/h2>\n

MOTS-c has been investigated in mitochondrial biology through:<\/p>\n

Nuclear Translocation \u2014 Moves to the nucleus under metabolic stress to regulate adaptive gene expression.<\/p>\n

Oxidative Stress Resistance \u2014 Enhances cellular defense against oxidative damage.<\/p>\n

Energy Homeostasis Regulation \u2014 Supports mitochondrial function and ATP production pathways.<\/p>\n

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Supporting Studies:<\/strong><\/span><\/h3>\n

Kim, K.H. et al. \u2014 Nature Communications.<\/p>\n

\u201cMOTS-c translocates to the nucleus to regulate stress-responsive gene expression.\u201d<\/p>\n

\u25a0 PubMed \u2013 PMID: 28128265<\/p>\n

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Aging & Longevity Research<\/strong><\/span><\/h2>\n

MOTS-c has been explored in aging-related studies through:<\/p>\n

Longevity Pathway Activation \u2014 Associated with metabolic regulation pathways linked to lifespan extension.<\/p>\n

Exercise-Mimetic Effects \u2014 Demonstrates exercise-like metabolic benefits in experimental models.<\/p>\n

Cellular Adaptation Mechanisms \u2014 Enhances resilience to metabolic stress and age-related decline.<\/p>\n

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Supporting Studies:<\/strong><\/span><\/h3>\n

Reynolds, J.C. et al. \u2014 Nature Communications.<\/p>\n

\u201cMOTS-c promotes metabolic homeostasis and physical capacity in aging models.\u201d<\/p>\n

\u25a0 PubMed \u2013 PMID: 32210205<\/p>\n

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Recommended Research Concentrations<\/strong><\/span><\/h2>\n

Note: For laboratory research reference only. Not for human or veterinary use.<\/p>\n

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Research Model<\/p>\n

Suggested Concentration<\/p>\n

Administration<\/p>\n

In-vitro metabolic assays<\/p>\n

1\u201310 \u00b5M<\/p>\n

Cell culture media<\/p>\n

Mitochondrial function studies<\/p>\n

1\u201320 \u00b5M<\/p>\n

Cell culture media<\/p>\n

Animal models (rodents, SC\/IP)<\/p>\n

0.1\u20131 mg\/kg<\/p>\n

Injection<\/p>\n

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Why Choose Primal Research for Your MOTS-c Research?<\/strong><\/span><\/h2>\n

\u226598% HPLC-verified purity \u2014 critical for mitochondrial signaling and metabolic pathway studies<\/p>\n

Independent third-party batch testing with COA available on request<\/p>\n

Lyophilized powder for maximum stability and long-term storage<\/p>\n

Available in 10mg, 20mg, and 40mg quantities \u2014 supports both small-scale and extended research protocols<\/p>\n

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Storage & Handling<\/strong><\/span><\/h2>\n

Store at -20\u00b0C, desiccated and protected from light<\/p>\n

Soluble in sterile water or bacteriostatic water<\/p>\n

Prepare fresh solutions prior to each experiment<\/p>\n

Avoid repeated freeze-thaw cycles<\/p>\n

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Technical Specifications<\/strong><\/span><\/h2>\n

Compound: MOTS-c<\/p>\n

Molecular Weight: ~2174 g\/mol<\/p>\n

Purity: \u226598% (HPLC Verified)<\/p>\n

Form: Lyophilized powder \u2014 available in 10mg, 20mg, and 40mg<\/p>\n

Storage: -20\u00b0C, desiccated, light-protected<\/p>\n

Solubility: Soluble in sterile water or bacteriostatic water<\/p>\n

COA: Available per batch on request<\/p>\n

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Advance Your Metabolic & Mitochondrial Research<\/strong><\/span><\/h2>\n

Order your MOTS-c today to support advanced research in metabolic regulation, mitochondrial biology, and cellular energy systems.<\/p>\n

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Primal Research products are sold strictly for in-vitro and laboratory research use only.<\/p>\n

Not for human or veterinary consumption.<\/p>\n

Not intended to diagnose, treat, cure, or prevent any disease or condition.<\/p>\n

Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"excerpt":{"rendered":"

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"featured_media":245,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[85],"product_tag":[],"class_list":["post-534","product","type-product","status-publish","has-post-thumbnail","product_cat-cellular-energy-research","pa_packaging-10mg","pa_packaging-20mg","pa_packaging-40mg","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product\/534","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media\/245"}],"wp:attachment":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media?parent=534"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_brand?post=534"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_cat?post=534"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_tag?post=534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}