{"id":542,"date":"2026-03-31T23:55:30","date_gmt":"2026-03-31T23:55:30","guid":{"rendered":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/?post_type=product&p=542"},"modified":"2026-09-02T20:33:44","modified_gmt":"2026-09-02T20:33:44","slug":"epithalon","status":"publish","type":"product","link":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/product\/epithalon\/","title":{"rendered":"Epithalon"},"content":{"rendered":"

Epithalon \u2014 10mg | 50mg<\/strong><\/span><\/h2>\n

Telomerase-Activating Tetrapeptide | Longevity & Cellular Aging Research Compound<\/strong><\/span><\/h3>\n
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\u25a0 For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.<\/p>\n

Intended exclusively for in-vitro and laboratory research by qualified investigators.<\/p>\n

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Epithalon \u2013 10mg \/ 50mg \u2013 A Telomerase-Activating Peptide for Longevity and Cellular Aging Research<\/strong><\/p>\n

Category:<\/strong> Peptide Research Compounds \/ Longevity Research \/ Telomere Biology & Cellular Aging<\/p>\n

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Disclaimer:<\/strong><\/span><\/h2>\n

ATTENTION: PRIMALRESEARCHLABS.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY.<\/p>\n

All information presented on this site is for educational and research purposes related to scientific investigation.<\/p>\n

These products are strictly not for human or veterinary use, consumption, or diagnostic applications.<\/p>\n

They are not pharmaceuticals, food additives, or dietary supplements.<\/p>\n

By purchasing from PrimalResearchLabs.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment.<\/p>\n

You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals.<\/p>\n

Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.<\/p>\n

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Biology<\/strong><\/span><\/h2>\n

Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide analog of the naturally occurring pineal peptide Epithalamin, designed to investigate mechanisms of cellular aging, telomere dynamics, and circadian regulation.<\/p>\n

It has been extensively studied in preclinical and clinical research models for its ability to activate telomerase, elongate telomeres, and modulate gene expression associated with cellular lifespan and genomic stability.<\/p>\n

Epithalon is of particular interest in longevity research due to its reported influence on chromosomal integrity, oxidative stress regulation, and pineal gland signaling pathways.<\/p>\n

Its small molecular structure and stability make it a versatile tool for in-vitro and in-vivo experimental design across aging, regenerative biology, and endocrine signaling studies.<\/p>\n

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.<\/p>\n

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Key Research Applications of Epithalon<\/strong><\/span><\/h2>\n

1. Telomere Biology & Cellular Senescence Research<\/strong><\/span><\/h3>\n

Epithalon has demonstrated significant activity in telomere-related studies through:<\/p>\n

Telomerase Activation \u2014 Induces telomerase expression in human somatic cell cultures, leading to elongation of telomeres and delayed replicative senescence (Khavinson et al.).<\/p>\n

Chromosomal Stability \u2014 Associated with reduced chromosomal aberrations and enhanced DNA integrity in aging cell populations.<\/p>\n

Extended Cellular Lifespan \u2014 Increased proliferative capacity observed in fibroblast cultures, supporting its role in cellular longevity research models.<\/p>\n

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Supporting Studies:<\/strong><\/span><\/h3>\n

Khavinson, V. et al. \u2014 Bulletin of Experimental Biology and Medicine.<\/p>\n

\u201cEpithalon induced telomerase activity and telomere elongation in human somatic cells, contributing to extended cellular lifespan in vitro.\u201d<\/p>\n

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2. Pineal Gland Function & Circadian Rhythm Research<\/strong><\/span><\/h2>\n

Epithalon has been investigated for its role in neuroendocrine regulation through:<\/p>\n

Melatonin Secretion Modulation \u2014 Stimulates pineal gland activity, increasing melatonin production in aging animal models.<\/p>\n

Circadian Rhythm Regulation \u2014 Restores disrupted circadian cycles, making it a valuable tool in chronobiology research.<\/p>\n

Neuroendocrine Axis Support \u2014 Influences hypothalamic-pituitary signaling pathways linked to aging and hormonal balance.<\/p>\n

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Supporting Studies:<\/strong><\/span><\/h3>\n

Anisimov, V.N. et al. \u2014 Neuroendocrinology Letters.<\/p>\n

\u201cEpithalon administration restored melatonin production and improved circadian rhythm regulation in aged animal models.\u201d<\/p>\n

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3. Oxidative Stress & Longevity Pathway Research<\/strong><\/span><\/h2>\n

Epithalon has been explored in oxidative stress and aging-related pathways through:<\/p>\n

Antioxidant Enzyme Activation \u2014 Upregulates endogenous antioxidant systems, including superoxide dismutase (SOD) and catalase.<\/p>\n

Reduced Lipid Peroxidation \u2014 Demonstrates decreased markers of oxidative damage in cellular and animal models.<\/p>\n

Longevity-Associated Effects \u2014 Long-term studies in animal models have reported increased lifespan and improved physiological markers of aging.<\/p>\n

\n

Supporting Studies:<\/strong><\/span><\/h3>\n

Anisimov, V.N. et al. \u2014 Annals of the New York Academy of Sciences.<\/p>\n

\u201cLong-term Epithalon administration was associated with increased lifespan and reduced incidence of age-related pathologies in animal models.\u201d<\/p>\n

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Recommended Research Concentrations<\/strong><\/span><\/h2>\n

Note: For laboratory research reference only. Not for human or veterinary use.<\/p>\n

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Research Model
Suggested Concentration
Administration<\/p>\n

In-vitro cell culture studies
1\u2013100 \u00b5M
Cell culture media<\/p>\n

Telomerase activity assays
10\u201350 \u00b5M
Assay buffer<\/p>\n

Animal models (rodents, SC\/IP)
0.1\u20131 mg\/kg
Injection<\/p>\n

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Why Choose Primal Research for Your Epithalon Research?<\/strong><\/span><\/h2>\n

\u226598% HPLC-verified purity \u2014 critical for telomerase and gene expression studies<\/p>\n

Independent third-party batch testing with COA available on request<\/p>\n

Lyophilized powder for maximum stability and long-term storage<\/p>\n

Available in 10mg and 50mg quantities \u2014 supports both small-scale and extended research protocols<\/p>\n

\n

Storage & Handling<\/strong><\/span><\/h2>\n

Store at -20\u00b0C, desiccated and protected from light<\/p>\n

Soluble in sterile water or appropriate aqueous buffer<\/p>\n

Prepare fresh solutions prior to each experiment<\/p>\n

Avoid repeated freeze-thaw cycles<\/p>\n

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Technical Specifications<\/strong><\/span><\/h2>\n

Compound: Epithalon (Ala-Glu-Asp-Gly)<\/p>\n

Molecular Weight: 390.35 g\/mol<\/p>\n

Molecular Formula: C14H22N4O9<\/p>\n

Purity: \u226598% (HPLC Verified)<\/p>\n

Form: Lyophilized powder \u2014 available in 10mg and 50mg<\/p>\n

Storage: -20\u00b0C, desiccated, light-protected<\/p>\n

Solubility: Soluble in sterile water or aqueous buffer<\/p>\n

COA: Available per batch on request<\/p>\n

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Advance Your Longevity Research<\/strong><\/span><\/h2>\n

Order your Epithalon (10mg or 50mg) today to support advanced research in telomere biology, cellular aging, and longevity science.<\/p>\n

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Final Disclaimer:<\/strong><\/span><\/h2>\n

Primal Research products are sold strictly for in-vitro and laboratory research use only.<\/p>\n

Not for human or veterinary consumption.<\/p>\n

Not intended to diagnose, treat, cure, or prevent any disease or condition.<\/p>\n

Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"excerpt":{"rendered":"

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"featured_media":490,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[85],"product_tag":[],"class_list":["post-542","product","type-product","status-publish","has-post-thumbnail","product_cat-cellular-energy-research","pa_packaging-10mg","pa_packaging-50mg","first","instock","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product\/542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media\/490"}],"wp:attachment":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media?parent=542"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_brand?post=542"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_cat?post=542"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_tag?post=542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}