{"id":548,"date":"2026-03-31T23:59:30","date_gmt":"2026-03-31T23:59:30","guid":{"rendered":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/?post_type=product&p=548"},"modified":"2026-09-02T20:27:00","modified_gmt":"2026-09-02T20:27:00","slug":"nad","status":"publish","type":"product","link":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/product\/nad\/","title":{"rendered":"NAD+"},"content":{"rendered":"

Nicotinamide Adenine Dinucleotide | Cellular Energy & Redox Biology Research Compound<\/strong><\/span><\/h2>\n
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\u25a0 For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.<\/p>\n

Intended exclusively for in-vitro and laboratory research by qualified investigators.<\/p>\n

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NAD+ \u2013 500mg \u2013 A Central Coenzyme for Cellular Energy and Redox Biology Research<\/strong><\/p>\n

Category:<\/strong> Small Molecule Research Compounds \/ Metabolic Research \/ Cellular Bioenergetics<\/p>\n

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Disclaimer:<\/strong><\/span><\/h2>\n

ATTENTION: PRIMALRESEARCHLABS.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY.<\/p>\n

All information presented on this site is for educational and research purposes related to scientific investigation.<\/p>\n

These products are strictly not for human or veterinary use, consumption, or diagnostic applications.<\/p>\n

They are not pharmaceuticals, food additives, or dietary supplements.<\/p>\n

By purchasing from PrimalResearchLabs.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment.<\/p>\n

You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals.<\/p>\n

Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.<\/p>\n

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Biology<\/strong><\/span><\/h2>\n

Nicotinamide adenine dinucleotide (NAD+) is a central coenzyme present in all living cells, playing a critical role in redox reactions, cellular energy production, and metabolic regulation.<\/p>\n

It functions as an essential electron carrier in mitochondrial oxidative phosphorylation and glycolysis, enabling ATP generation and maintaining cellular energy balance.<\/p>\n

NAD+ is of particular interest in metabolic and aging research due to its role as a substrate for sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38 enzymes, which are involved in DNA repair, gene expression regulation, and cellular stress responses.<\/p>\n

Declining NAD+ levels have been associated with aging and metabolic dysfunction, making it a valuable compound for in-vitro and in-vivo experimental design across bioenergetics, longevity research, and cellular resilience studies.<\/p>\n

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.<\/p>\n

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Key Research Applications of NAD+<\/strong><\/span><\/h2>\n

Cellular Energy Production & Mitochondrial Function Research<\/strong><\/span><\/h3>\n

NAD+ has demonstrated essential activity in cellular bioenergetics through:<\/p>\n

Electron Transport Chain Function \u2014 Serves as a key cofactor in mitochondrial ATP production via oxidative phosphorylation.<\/p>\n

Redox Balance Regulation \u2014 Maintains NAD+\/NADH ratio critical for metabolic homeostasis.<\/p>\n

Mitochondrial Efficiency \u2014 Supports cellular respiration and energy metabolism pathways.<\/p>\n

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Supporting Studies:<\/strong><\/p>\n

Verdin, E. \u2014 Science.<\/p>\n

\u201cNAD+ metabolism plays a central role in mitochondrial function and cellular energy homeostasis.\u201d<\/p>\n

\u25a0 PubMed \u2013 PMID: 26430185<\/p>\n

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Sirtuin Activation & Aging Research<\/strong><\/span><\/h2>\n

NAD+ has been extensively studied in longevity and cellular aging pathways through:<\/p>\n

Sirtuin Activation \u2014 Acts as a required cofactor for SIRT1\u2013SIRT7 enzymes regulating gene expression and longevity pathways.<\/p>\n

DNA Repair Mechanisms \u2014 Supports PARP-mediated DNA repair and genomic stability.<\/p>\n

\u2022 Age-Related Decline Studies \u2014 Reduced NAD+ levels are associated with aging and metabolic dysfunction in research models.<\/p>\n

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Supporting Studies:<\/strong><\/p>\n

Imai, S. & Guarente, L. \u2014 Nature.<\/p>\n

\u201cNAD+ and sirtuins play a critical role in aging and metabolic regulation.\u201d<\/p>\n

\u25a0 PubMed \u2013 PMID: 21376309<\/p>\n

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Metabolic Regulation & Cellular Stress Response Research<\/strong><\/span><\/h2>\n

NAD+ has been explored in metabolic and stress response studies through:<\/p>\n

Glucose Metabolism Regulation \u2014 Influences glycolysis and insulin sensitivity pathways.<\/p>\n

Oxidative Stress Resistance \u2014 Supports cellular defense against oxidative damage.<\/p>\n

Inflammatory Pathway Modulation \u2014 Participates in regulation of immune and stress signaling pathways.<\/p>\n

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Supporting Studies:<\/strong><\/p>\n

Yoshino, J. et al. \u2014 Cell Metabolism.<\/p>\n

\u201cNAD+ intermediates enhance metabolic function and insulin sensitivity.\u201d<\/p>\n

\u25a0 PubMed \u2013 PMID: 23217256<\/p>\n

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Recommended Research Concentrations<\/strong><\/span><\/h2>\n

Note: For laboratory research reference only. Not for human or veterinary use.<\/p>\n

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Research Model<\/p>\n

Suggested Concentration<\/p>\n

Administration<\/p>\n

In-vitro metabolic assays<\/p>\n

10\u2013500 \u00b5M<\/p>\n

Cell culture media<\/p>\n

Mitochondrial studies<\/p>\n

50\u2013500 \u00b5M<\/p>\n

Cell culture media<\/p>\n

Animal models (rodents, IP\/IV)<\/p>\n

10\u2013500 mg\/kg<\/p>\n

Injection<\/p>\n

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Why Choose Primal Research for Your NAD+ Research?<\/strong><\/span><\/h2>\n

\u226598% purity \u2014 critical for bioenergetics and enzymatic pathway studies<\/p>\n

Independent third-party batch testing with COA available on request<\/p>\n

High-stability formulation for controlled experimental use<\/p>\n

Available in 500mg quantity \u2014 supports advanced metabolic and longevity research protocols<\/p>\n

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Storage & Handling<\/strong><\/span><\/h2>\n

Store at -20\u00b0C, desiccated and protected from light<\/p>\n

Soluble in sterile water or bacteriostatic water; for optimal stability, sterile water or buffered solutions are recommended<\/p>\n

Prepare fresh solutions prior to each experiment<\/p>\n

Avoid repeated freeze-thaw cycles<\/p>\n

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Technical Specifications<\/strong><\/span><\/h2>\n

Compound: Nicotinamide Adenine Dinucleotide (NAD+)<\/p>\n

Molecular Weight: ~663.4 g\/mol<\/p>\n

Molecular Formula: C21H27N7O14P2<\/p>\n

Purity: \u226598%<\/p>\n

Form: Lyophilized powder \u2014 available in 500mg<\/p>\n

Storage: -20\u00b0C, desiccated, light-protected<\/p>\n

Solubility: Soluble in sterile water or bacteriostatic water<\/p>\n

COA: Available per batch on request<\/p>\n

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Advance Your Cellular Energy & Longevity Research<\/strong><\/span><\/h2>\n

Order your NAD+ 500mg today to support advanced research in mitochondrial function, metabolic regulation, and aging biology.<\/p>\n

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Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption.<\/p>\n

Not intended to diagnose, treat, cure, or prevent any disease or condition.<\/p>\n

Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"excerpt":{"rendered":"

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.<\/p>\n","protected":false},"featured_media":465,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[85],"product_tag":[],"class_list":["post-548","product","type-product","status-publish","has-post-thumbnail","product_cat-cellular-energy-research","pa_packaging-500mg","first","instock","featured","shipping-taxable","purchasable","product-type-variable"],"acf":[],"_links":{"self":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product\/548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media\/465"}],"wp:attachment":[{"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/media?parent=548"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_brand?post=548"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_cat?post=548"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/primalre.dalult4.hostarmada.net\/newwebsite\/wp-json\/wp\/v2\/product_tag?post=548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}